The Functional Roles of APP Cytoplasmic Domain—Conflicts and Consensus
Fe65 knockout (KO) mice (see Guenette et al., 2006) and Ulrike Muller showed with her APP triple KO
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Fe65 knockout (KO) mice (see Guenette et al., 2006) and Ulrike Muller showed with her APP triple KO
(Galvin et al., 2005). Brief cognitive tests such as the Mini Mental State Examination (MMSE) may help
using different techniques, this might be a reasonable resource (Wu et al., 2007). Kenneth Kosik Once
flow. (Editor’s note: see recent paper about connectivity data in young ApoE4 data: Filippini et al.,
covered this important milestone with commentary (see Dubois et al., 2007), in the news (see ARF related
Südhof, 2008, review; Yanagi et al., 2012; Sun et al., 2011; Qi et al., 2009). Two papers in the October
accumulate less amyloid in the brain (see ARF related news story; Arendash et al., 2004; Jankowsky et al.,
(Seubert et al., 1992; Haass et al., 1992). All the same, a parallel line of inquiry challenging the
factor for LOAD (Aldudo et al., 1998; Zekanowski et al., 2004; Helisalmi et al., 2000). Other presenilin
appeared in the October-December 2006 supplement. Steve Ferris et al. 0 WEBINAR Monday, March 12, 2007-
(Nunomura et al., 2004) showing that where Aβ exists, there is actually less evidence of oxidative stress in
Aβ production that might be regulated by synaptic activity (Kamenetz et al., 2003; Bero et al., 2011)
influence biology in people with Down’s (see Korbel et al., 2009), the presence of an extra copy of the gene
(i.e., their evolution over the course of the disease) (Jack et al., 2010; Weiner et al., 2010; Frisoni
Petersen criteria for amnestic MCI (Petersen et al., 1999; Petersen, 2004), though the memory impairment
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